The lack of just one of the hormone cortisol can lead to catastrophic consequences for the whole organism. If you feel unwell, weakness, change overall health – don’t wait, call your doctor. Timely diagnosis and treatment will help maintain health for many years
Cortisol – a hormone produced by the fascicular zone of the adrenal cortex. Man it is extremely necessary, because it performs several vital functions. The hormone increases the formation of protein in the liver with the formation of a number of aminotransferases – specific enzymes connecting protein and carbohydrate metabolism.
Low cortisol: symptoms, diagnosis and how to raise
- Symptoms of low cortisol
- Diagnosis of the disease
- How to increase cortisol
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In muscle tissues cortisol does the opposite – causes enhanced protein breakdown. The main effect of cortisol is the inhibition of the capture and absorption of glucose by the peripheral tissues (adipose and lymphoid) and the inhibition of the synthesis of insulin, so the hormone is directly involved in carbohydrate metabolism.
The content of cortisol in humans depends on a circadian rhythm. After a night of sleep its level begins to increase, by the time the Wake reaches the maximum numbers and begins to decline in the morning. During the day the amount of cortisol remains very low, after falling asleep, the cycle repeats.
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A steroid hormone important for the normal functioning of the human body. The decline in the blood indicates the presence of serious pathology:
- Tuberculous lesions of the adrenal glands
- Addison’s Disease
- Congenital adrenal hyperplasia
- Hypopituitarism (pituitary insufficiency) and hypopituitarism (hormone deficiency, hypothalamo-adeno-hypophyseal system)
- Iatrogenic exposure (removal of the adrenal glands, certain medications)
Symptoms of low cortisol
Reduced cortisol has about the same symptoms, though there are some differences that depend on the specific disease.
Addison’s disease, tuberculosis, and congenital dysfunction lead to chronic adrenal insufficiency. Patients begin to complain of quick fatigue, fatigue, muscular weakness, progressive weight loss, apathy, loss of interest in life.
The main feature of chronic failure, increased pigmentation of the skin. This is especially noticeable in areas of friction with clothing, nipple areola, around the anus, postoperative scars. A sharp increase in pigmentation indicates increasing severity of the disease and the approach addisonicescom crisis (acute adrenal insufficiency).
The earliest symptom of low cortisol and chronic adrenal insufficiency is hypotension – ongoing low blood pressure. Systolic pressure in patients 110-90 mm Hg., diastolic – 70 and below.
Frequent manifestation of the lack of cortisol is dizziness, fainting, hypoglycemic condition, an increased heart rate. The rate of weight loss depends on the degree of lack of appetite. Often patients complain of abdominal pain is unclear localization.
Often, patients are registered with a gastroenterologist spastic colitis, ulcerative lesions of intestine and stomach, which leads to late diagnosis of low cortisol and adrenal insufficiency. If the cortisol is lowered in women, there is okuneye menstruation until their complete absence.
Gipopituitrizm and hypopituitarism are characterized by a decrease production of pituitary hormones, this leads to the fact that cortisol in the blood is lowered. The symptoms are very variable and consist of signs of insufficiency of a hormone and neurovegetative disorders. Patients has been steadily decreasing body weight, the skin becomes dry, wrinkled, break and fall out hair. Patients complain sharp weakness, intolerance to exercise, lethargy, up to complete immobilization.
Especially revealing are the symptoms of sexual dysfunction. Lost libido, loss of hair on the pubes and in the armpits. In women missing periods, atrophy of the mammary glands, pigmentation of nipples is lost. In men atrophy of the testes, seminal vesicles, prostate and penis.
The fall of cortisol and hypothyroidism (reduction of thyroid hormones) leads to coma in these patients. Also a small amount of adrenal hormone causing dyspepsia with nausea and vomiting, abdominal pain due to spasm of smooth muscles, decrease of secretory activity of the pancreas and intestines.
Iatrogenic effects play an important role in hormonal balance. The Nelson syndrome first described in 1958 – appears at patients who survived the destruction of the adrenal glands. Characterized by the appearance of ACTH-producing pituitary tumors, ophthalmologic and neurological disorders. Patients prone to anxiety, suspiciousness, depression, increased anxiety. Reduced vision with loss of fields and sometimes it is a loss. Many develop neoplastic process – the appearance of tumors in various organs.
Diagnosis of the disease
The diagnosis of low cortisol consists of laboratory and instrumental studies.
- General blood analysis: leucopenia, lymphocytosis, ESR acceleration, hypochromic anemia
- Biochemical analysis of blood – decrease sodium, increase potassium, increase in creatinine and urea
- Definition of cortisol in the blood several times during the day
- Radiography for detection of tuberculosis
- X-ray bone detection of dilution of the tissue to detect osteoporosis
- MRI of the brain and spinal cord, MRI of the pituitary gland
- Test insulin hypoglycaemia – the introduction of a few units of insulin depending on the body mass will not lead to a significant increase in ACTH and cortisol that will talk about the secondary gipokortitsizm.
- Abdominal ultrasound
How to increase cortisol
To raise cortisol can be a purpose of its synthetic analogues: hydrocortisone acetate, prednisolone, cortisone. Substitution therapy is prescribed by a doctor and requires control of the hormone in the blood. preparations are issued in tablets and a solution for suspension. Depending on the severity of the condition are appointed inside, intramuscularly or intravenously.
To raise the amount of cortisol in some cases resorting to following simple tips:
- Go to bed at the same time, preferably no later than 10 PM. Ensure complete darkness and silence, a good night’s sleep increases the synthesis of cortisol.
- Eat more fruits, especially grapefruits
- Licorice helps restore hormonal balance – it can be consumed in form of supplements, tablets
- Listen to classical music, pray – it will restore the emotional background, reduce the response to different stresses, which will reduce the constant release of cortisol.
The lack of just one hormone can lead to disastrous consequences for the whole organism. If you feel unwell, weakness, change overall health – don’t wait, call your doctor. Timely diagnosis and treatment will help maintain health for many years.published econet.ru.
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